When the air turns crisp and cozy evenings beg for something warm and satisfying, there’s one dish that never fails to deliver: Chicken Pot Pie Bubble Up Casserole. This recipe is the perfect blend of nostalgic comfort food and modern ease, ideal for a family dinner on a chilly night or a hearty potluck dish that impresses without the stress.

The inspiration for this dish comes from the traditional chicken pot pie — a beloved staple in many households — but with a twist that makes it faster and even more crave-worthy. Instead of painstakingly preparing pie crusts, this casserole “bubbles up” with pieces of biscuit dough that bake to golden perfection, nestled in a creamy, savory filling. It’s a shortcut that doesn’t skimp on flavor — just on time.

Let’s dive into this delightful dish that’s guaranteed to become a regular on your dinner table.

Why You’ll Love This Chicken Pot Pie Bubble Up Casserole

This recipe combines the classic flavor of chicken pot pie with the convenience of a casserole. Here’s why it stands out:

• Quick and easy prep: Using store-bought biscuit dough and pre-cooked chicken slashes your kitchen time in half.

• One-pan meal: Everything bakes together in one dish, making cleanup simple.

• Family-friendly: The creamy filling and flaky biscuit topping appeal to all ages.

• Perfect for leftovers: It reheats beautifully and makes a great lunch the next day.

• Comfort food made easy: All the flavor and heartiness of a classic dish with half the effort.

Whether you’re cooking for a busy weeknight or preparing a cozy Sunday dinner, this recipe is your shortcut to a soul-warming meal.

Ingredients You’ll Need

To create this bubbling, savory casserole, you’ll need just a handful of ingredients — most of which you might already have in your kitchen.

Main Ingredients:

• 2 cups cooked chicken, shredded or diced (rotisserie works great)

• 1 can (10.5 oz) cream of chicken soup

• 1/2 cup sour cream

• 1/2 cup milk

• 2 cups frozen mixed vegetables (peas, carrots, corn, and green beans work well)

• 1/2 teaspoon garlic powder

• 1/2 teaspoon onion powder

• Salt and pepper to taste

• 1 can (16.3 oz) refrigerated biscuit dough, cut into quarters (like Pillsbury Grands)

• 1 cup shredded cheddar cheese (optional, but highly recommended)

Optional Add-Ins:

• 1/4 tsp dried thyme or rosemary

• 1/2 cup cooked bacon or diced ham

• Dash of hot sauce for a slight kick

These ingredients come together quickly and create a filling, flavorful dish that’s perfect for any night of the week.

Step-by-Step Instructions

Here’s how to bring this bubbling comfort food to life.

1. Preheat and Prep

Preheat your oven to 350°F (175°C). Lightly grease a 9×13-inch baking dish or spray with non-stick cooking spray.

2. Make the Filling

In a large mixing bowl, stir together:

• Cream of chicken soup

• Sour cream

• Milk

• Garlic powder

• Onion powder

• Salt and pepper

• Frozen mixed vegetables

• Cooked chicken

Mix everything until it’s well combined and evenly coated. This will be your rich and creamy pot pie base.

3. Cut and Toss the Biscuits

Open the can of refrigerated biscuit dough and cut each biscuit into quarters. This helps them cook evenly and bubble up beautifully during baking.

Gently fold the biscuit pieces into the filling mixture, ensuring each one is coated in the sauce.

4. Assemble the Casserole

Pour the entire mixture into your prepared baking dish. Spread it out evenly and sprinkle the shredded cheddar cheese over the top (if using).

5. Bake to Golden Perfection

Place the dish in the oven and bake for 35 to 40 minutes, or until the biscuits are golden brown on top and cooked through. The casserole should be bubbly around the edges, and the biscuits should feel firm when pressed gently.

6. Cool and Serve

Let the casserole sit for about 5 minutes before serving. This helps everything set up slightly and makes for easier scooping.

Tips for Success

Making this casserole is straightforward, but here are a few pro tips to ensure it turns out perfect every time:

1. Use Rotisserie Chicken for Speed

Rotisserie chicken is a fantastic time-saver. It’s flavorful, moist, and ready to go, making this recipe even quicker.

2. Don’t Overcrowd the Biscuits

Cutting the biscuits into quarters helps them cook through, but make sure they’re evenly distributed in the mixture. Avoid clumping them together.

3. Cover if Needed

If the top is browning too quickly but the biscuits aren’t done, loosely cover the dish with foil and continue baking until fully cooked.

4. Customize to Taste

Feel free to mix in other veggies like mushrooms, chopped spinach, or broccoli. A little Parmesan or mozzarella cheese on top can also add an extra savory layer.

Storage and Reheating

This casserole stores well and tastes just as good the next day.

To Store:

Allow leftovers to cool completely, then cover the dish with foil or transfer to an airtight container. Refrigerate for up to 4 days.

To Reheat:

Reheat individual servings in the microwave for 1-2 minutes, or rewarm the whole casserole in the oven at 325°F for 15-20 minutes, covered with foil to prevent drying out.

To Freeze:

Freeze fully baked and cooled portions in airtight containers for up to 3 months. Thaw overnight in the fridge and reheat as above.

Make It Ahead

Want to get a jump start on dinner? You can assemble the casserole up to 24 hours in advance. Just cover it tightly and store in the fridge. When you’re ready to bake, let it sit at room temperature for about 20 minutes while the oven preheats.

Alternatively, prepare the filling ahead of time and keep the biscuit dough separate until you’re ready to bake.

What to Serve with Chicken Pot Pie Bubble Up Casserole

This hearty casserole is a meal in itself, but you can round it out with a few simple sides:

• Green salad with vinaigrette

• Roasted Brussels sprouts or green beans

• Fresh fruit salad for a refreshing finish

• Homemade applesauce or cranberry sauce for a hint of sweetness

For drinks, consider iced tea, lemonade, or even a crisp white wine like Chardonnay or Pinot Grigio to complement the creamy richness of the dish.

Why It’s Great for Entertaining

Need a crowd-pleasing dish for a game night, potluck, or casual gathering? This casserole checks all the boxes:

• Feeds a crowd

• Travels well

• Satisfies all ages

• Easy to double or make in batches

You can bake it in a disposable foil tray for easy transport and cleanup, and it pairs beautifully with just about any side.

Variations to Try

Feel like switching things up? Here are a few fun ways to adapt this casserole to suit your preferences:

1. Turkey Bubble Up Casserole

Swap the chicken for leftover roasted turkey — perfect for post-holiday meals.

2. Veggie-Loaded Version

Use extra veggies and skip the meat for a vegetarian-friendly twist. A creamy mushroom soup base works great here.

3. Buffalo Chicken Style

Add a few tablespoons of buffalo sauce to the mix and top with blue cheese crumbles for a spicy kick.

4. Southwestern Version

Mix in black beans, corn, diced green chilies, and taco seasoning. Swap the cream of chicken soup for a cream of mushroom or cheddar version.

Each variation keeps the heart of the recipe intact while adding a new flavor profile to keep things interesting.

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